Bone quality and osteoporosis therapy

Bone quality and osteoporosis therapy.

Although BMD measured by DXA is a useful clinical tool for osteoporosis diagnosis, changes resulting from osteoporosis treatment only partially explain the observed reduction in fractures. Several other bone properties that influence its resistance to fractures and explain this discrepancy have been defined as "bone quality". Bone quality is determined by its structural and material properties ...

Bone markers and osteoporosis therapy.

Several factors are involved in determining bone quality including bone density, bone turnover, the extent of trabecular bone connectivity, cortical porosity and geometry. Metabolically active and in a continuous process of remodeling, approximately 20% of bone tissue is renewed annually. Bone turn over markers (BTM) are frequently used in clinical trials and to provide valid information about ...

Osteoporosis and fracture risk: bone matrix quality.

Effects of osteoporosis treatments on bone quality

to fracture. However, bones fracture for different reasons, so there are several different biomechanical definitions of bone fragility. One function of bones is to carry loads. Fractures occur when loads exceed the bone strength, so weakened bones should be considered fragile. For example osteoporotic vertebral bodies might fracture during normal daily activities like opening a window or rising...

Diseases affecting bone quality: beyond osteoporosis.

BACKGROUND Bone quantity, quality, and turnover contribute to whole bone strength. Although bone mineral density, or bone quantity, is associated with increased fracture risk, less is known about bone quality. Various conditions, including disorders of mineral homeostasis, disorders in bone remodeling, collagen disorders, and drugs, affect bone quality. QUESTIONS/PURPOSES The objectives of th...